https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Comparative leaching of a sulfidic gold ore in ionic liquid and aqueous acid with thiourea and halides using Fe(III) or HSO₅⁻ oxidant https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7233 Sat 24 Mar 2018 08:33:47 AEDT ]]> Small molecule inhibitors of protein kinases in cancer: how to overcome resistance https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:2784 Sat 24 Mar 2018 08:27:07 AEDT ]]> Scrambled and fried: cigarette smoke exposure causes antral follicle destruction and oocyte dysfunction through oxidative stress https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13898 Sat 24 Mar 2018 08:25:29 AEDT ]]> The effect of molecular structural variations on the CO<sub>2</sub> absorption characteristics of heterocyclic diamines for amine-based post combustion CO<sub>2</sub> capture https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13341 Sat 24 Mar 2018 08:17:00 AEDT ]]> The effect molecular structural variations has on the CO₂ absorption characteristics of heterocyclic amines https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17427 Sat 24 Mar 2018 08:01:40 AEDT ]]> Damaging legacy: maternal cigarette smoking has long-term consequences for male offspring fertility https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19563 Sat 24 Mar 2018 07:58:24 AEDT ]]> Chemoselective flow hydrogenation approaches to isoindole-7-carboxylic acids and 7-oxa-bicyclio[2.2.1]heptanes https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21034 Sat 24 Mar 2018 07:50:32 AEDT ]]> Potentiometric determination of acid dissociation constants of novel biaryl monomers https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26330 as) of a number of novel polymerisable vinyl biaryl compounds, 4-(4'-ethenylphenyl)-pyridine (M1), 4'-ethenyl-(1,1'-biphenyl)-4-ol (M2), 4'-ethenyl-N,N-dimethyl-(1,1'-biphenyl)-3-amine (M3), 4'-ethenyl-(1,1'-biphenyl)-4-methanol (M4), 4'-ethenyl-N,N-dimethyl-(1,1'-biphenyl)-4-amine (M5), 4'-ethenyl-(1,1'-biphenyl)-4-carboxylic acid (M6), 4'-ethenyl-4-hydroxy-5-methyl-(1,1'-biphenyl)-3-carboxaldehyde (M7) were determined in a mixed solvent (THF-water) potentiometric titration at 25 °C and subsequent extrapolation to pure water via the Yasuda-Shedlovsky method. The acidity and basicity of the compounds in THF-water mixtures was observed to decrease with increasing THF fraction and is attributed to the corresponding decrease in the dielectric constant of the solution. To the best of our knowledge, this is the first reported study of pKa values undertaken for this class of compounds. The biaryls, M1-M7, were prepared by microwave-assisted Suzuki cross coupling of 4-vinylphenyl boronic acid with the appropriate aryl bromide and were custom designed for use as functional monomers in the synthesis of molecularly imprinted polymers.]]> Sat 24 Mar 2018 07:35:56 AEDT ]]> Small molecules demonstrate the role of dynamin as a bi-directional regulator of the exocytosis fusion pore and vesicle release https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28297 Sat 24 Mar 2018 07:33:49 AEDT ]]> A novel naphthalimide that selectively targets breast cancer via the arylhydrocarbon receptor pathway https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38322 50 value of 100 nM is greater than 500-fold more sensitive to NAP-6 compared with other tumour derived cell models. Within 1 h exposure of these cells to NAP-6, CYP1A1 expression increases 25-fold, rising to 250-fold by 24 h. A smaller concurrent increase in CYP1A2 and CYP1B1 is also observed. Within 24 h these cells present with DNA damage as evident by enhanced H2AXγ expression, cell cycle checkpoint activation via increased CHK2 expression, S-phase cell cycle arrest and cell death. Specific small molecule inhibitors of the AHR and CYP1 family ameliorate these events. A positive luciferase reporter assay for NAP-6 induced XRE binding further confirms the role of the AHR in this phenomenon. Non-sensitive cell lines fail to show these biological effects. For the first time we identify 2-(2-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione as a new AHR ligand that selectively targets breast cancer.]]> Fri 03 Sep 2021 14:57:31 AEST ]]>